Lung tissue bioenergetics and caspase activity in rodents

Non-invasive approaches to tissue bioenergetics.

It is clear that continuous light affords a very limited window of opportunity for quantitative spectrophotometry of brain tissue. However, the number of qualitative applications which are available exemplify how this extremely simple technique can be applied to important medical problems. The development of devices which can measure directly the oxygen saturation of the brain is more complicat...

Effects of L-Carnitine on follicular reserve and Caspase-3 in transplanted mouse ovarian tissue

Introdution: One of the major challengs in ovarian tissue transplantation is overcomeing ischemia/ reperfusion injuries. During ischemia–reperfusion processes, oxygen free radicals constitute the most important component that induces damage of the grafted tissues. The aim of this study was to investigate the effect of L-Carnitine (LC) as an antioxidant on heterotopic transplantation of mouse ov...

A permanently charged tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents.

A quaternized form of tamoxifen (TAM), tamoxifen methiodide (TMI), was shown to demonstrate very low brain uptake compared to TAM and, unexpectedly, was considerably less estrogenic than TAM in the uterus. The agonist activity of TMI in the bone was similar to that of TAM. TMI manifested significant dose-dependent tumoricidal activity with a rapid onset of action against MCF-7 human breast canc...

Investigation of lung normal tissue doses in lung tumors radiation therapy using both gated and conventional radiotherapy

Introduction: In radiation therapy of lung tumors, respiratory motion causes target moving, so a larger margin is needed to cover the clinical target volume (CTV). With the margin increasing, a larger volume of normal tissue will be exposed to high-dose.  In this study, dosimetric parameters of normal lung tissue were compared between gated and conventional radiotherapy (RT), u...

Bioenergetics: Brown Adipose Tissue Bioenergetics: A New Methodological Approach (Adv. Sci. 4/2017)